UFC Fight Night 192: Smith vs. Spann was a mixed martial arts event produced by the Ultimate Fighting Championship that took place on September 18, 2021, at the UFC Apex facility in Enterprise, Nevada, part of the Las Vegas Metropolitan Area, United States. A light heavyweight bout between former UFC Light Heavyweight Championship title challenger Anthony Smith and Ryan Spann served as the main event.

• Ultimate Fighting Championship
• Anthony Smith
• Ryan Spann
• Ion Cuțelaba
• Devin Clark
• Ariane Lipski da Silva
• Mandy Böhm
• Arman Tsarukyan
• Christos Giagos