Night of Champions (2008) was a PPV presented by P&G's Gillette Fusion Power, which took place on June 29, 2008 at the American Airlines Center in Dallas, Texas. It was the first annual event to be promoted solely under the Night of Champions name and the eighth annual event under the Vengeance/Night of Champions chronology. It starred wrestlers from the Raw, SmackDown, and ECW brands. The main event was an interpromotional match for the WWE Championship between SmackDown representative, Triple H, and Raw representative, John Cena. The main match was also an interpromotional match for the World Heavyweight Championship between SmackDown representative, Edge, and Raw representative, Batista. The main match from the ECW brand was an interpromotional standard match involving three wrestlers for the ECW Championship featuring ECW's Mark Henry, Raw's Kane, and SmackDown's The Big Show.

• World Wrestling Entertainment (WWE)
• Paul Lévesque
• John Cena
• Adam Copeland
• Dave Bautista
• Chris Irvine
• Kofi Sarkodie-Mensah
• Robert Howard
• Cody Rhodes