Jejoongwon is the first modern hospital in Korea established in the Joseon era in 1885. Baek Do Yang is a nobleman who gives up his status to enter its ranks. Hwang Jung is a butcher's son who becomes a physician, while Seok Ran enters Jejoongwon as an interpreter but takes on medical training to become a doctor.

• Park Yong-woo
• Cha Jae Dol
• Han Hye-jin
• Geum Bo-ra
• Choi Ja-hye
• Ricky Kim
• Kang Nam-gil
• Cha Hwa-yeon